Vaugelade J 1, Pinchinat
Guiella G 3, Elguero E 4, Simondon F 4. Non-specific effects of vaccination
on child survival: follow up study in Burkina Faso. BMJ, 329(7478):1309.
1 UMR151, IRD, Montpellier, France.
2 BIOSTATEM, Nîmes, France.
3 Unité d'études et de recherche en démographie,
UERD, Ouagadougou, Burkina.
4 UR024, IRD, Montpellier, France.
Objective: To study the impact of childhood vaccination on mortality
before 2 years of age in a developing country.
Design: Prospective cohort study.
Setting: Rural communities in Burkina Faso.
Participants: 9085 children born in the study area between 1985 and 1993.
Main outcome measure: Child death rate.
Results: Mortality before 2 years of age was lower in the vaccinated
group: Children vaccinated with BCG only had significant lower mortality
(0.37 (95% confidence interval 0.29 to 0.48)). Those vaccinated with
diphtheria, tetanus and pertussis vaccine only also had lower mortality
(0.24 (0.13 to 0.43)). The second dose of diphtheria, tetanus and pertussis
vaccine was not associated with lower mortality (0.80 (0.58 to 1.12)).
Conclusion: Diphtheria, tetanus and pertussis vaccine as well as BCG
were associated with better childhood survival.