Delcourt C, Carriere I, Ponton-Sanchez
A, Lacroux A, Covacho MJ, Papoz L. Institut National de la Sante et de
la Recherche Medicale (INSERM), Montpellier, France. email@example.com
BACKGROUND: Exposure to light may be an important risk factor for the
development of cataracts.
OBJECTIVE: To present the relation of ambient solar radiation and professional
and leisure exposures to light with the different types of cataracts.
METHODS: Pathologies Oculaires Liees a l'Age (POLA) is a population-based
study on cataract and age-related macular degeneration and their risk
factors in 2584 residents of Sete (southern France). Cataract classification
was based on lens examination at slitlamp according to Lens Opacities
Classification System III. A questionnaire about light exposure was administered.
RESULTS: After multivariate adjustment, participants who had higher ambient
solar radiation had a 2.5-fold (95% confidence interval [CI], 1.2-5.0),
4.0-fold (95% CI, 2.0-8.0), and 2.9-fold (95% CI, 1.5-5.3) increased
risk of cortical and mixed cataract and cataract surgery, respectively.
Solar ambient radiation was not significantly associated with posterior
subcapsular and nuclear cataracts. By contrast, posterior subcapsular
cataracts were significantly associated with professional exposure to
sunlight (odds ratio [OR], 1.63; 95% CI, 1.01-2.63) and frequent use
of sunglasses (OR, 0.62; 95% CI, 0.43-0.90). Mixed cataract was also
associated with professional exposure to artificial light (OR, 3.02;
95% CI, 1.03-8.82).
CONCLUSION: Our study further confirms the role of sunlight exposure
in the pathogenesis of cataract, in particular in its cortical localization.